ILC 2024 – Archived

Watch the recordings from ILC 2024 below:

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Thank You to All Symposium Participants!

We hope the connections made and ideas shared here will continue to flourish and lead to impactful innovations.

Photos

Thanks Jos V. Desmedt for all the nice pictures:

Slides and Recordings

The recordings are now final, you can find them there on soon on the Youtube channel:

Summary slides of the breakout sessions are available under Speakers.

Archive of ILC 2024 Website:

Welcome to the ILC Symposium 2024 @ Leuven!

Welcome to the 2024 edition of the ILC Symposium fully dedicated to Lobular Breast Cancer, which will take place in Leuven on September 23-25 at the Irish College Leuven! Set against the backdrop of hope, education, and progress, this event promises to be a beacon of inspiration and empowerment for all.  

Amidst the challenges we face, there is strength in unity, and there is power in knowledge. Together, we will delve into the latest advancements in lobular breast cancer diagnosis, translational research, treatment modalities, survivorship strategies, and the vital role of advocacy in shaping a brighter future for those affected by this disease.  

Whether you are a seasoned healthcare professional, a passionate advocate, a survivor, or a dedicated scientist, this conference offers a welcoming space for collaboration, learning, and fostering meaningful connections.   

We eagerly await your presence in September 2024.  

Warmest regards,  

The scientific committee 

_{Photo credits: Jos V. Desmedt}

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Scientific Agenda

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Keynote Speakers

Speakers & Chairs

• Philippe Aftimos – Institut Bordet, BE
• Ron Bose – Washington University
• Val Brunton – University of Edinburgh, UK
• Matthew F. Covington – University of Utah Health, USA
• Patrick Derksen – UMC Utrecht, NL
• Elleke Dresen – UZ Leuven, BE
• Julia Foldi – UPMC, USA
• Rachel Jankowitz – University of Pennsylvania, USA
• Marleen Kok – Netherlands Cancer Institute, NL
• Christiane Kulh – University Hospital Aachen, DE
• Chris Lord – Institute for Cancer Research, UK
• Fatima Mechta-Grigoriou – Institut Curie, FR
• Jason Mouabbi – MD Anderson, USA
• Rita Mukthar – University of California San Francisco, USA
• Steffi Oesterreich – UPMC, USA
• Fresia Pareja – MSKCC, USA
• Anne Salomon – Institut Curie, FR
• Tanja Spanic – Europa Donna, IT

Breakout sessions

You can download the summary slides of each session by clicking on its name.

Standardization of pathological diagnosis

• Lounes Djerroudi – Institut Curie, FR
• Giuseppe Floris – UZ/KU Leuven, BE
• Myiesha Gibson – Independant Patient Advocate
• Laurie Hutcheson – Lobular Breast Cancer Alliance, USA
• Tone Lien – EBLCAdvocates
• Fresia Pareja – MSKCC, USA
• Anne Salomon – Institut Curie, FR
• Stuart Schnitt – Dana-Farber Brigham Cancer Center, USA
• Gitte Zels – KU Leuven, BE

Imaging primary and metastatic ILC

• Matthew F. Covington – University of Utah Health, USA
• Elleke Dresen – UZ Leuven, BE
• Julia Foldi – UPMC, USA
• Christine Houser – Lobular Breast Cancer Alliance, USA
• Christiane Kulh – University Hospital Aachen, DE
• Caroline Malhaire – Institut Curie, FR
• Jason A. Mouabbi – MD Anderson, USA
• Kirstin Spencer – Lobular Breast Cancer Alliance, USA and METUP UK
• Karen Van Baelen – KU Leuven, BE
• Vincent Vandecaveye – UZ Leuven, BE

Dormancy: clinical challenges and experimental modeling

• Philippe Aftimos – Institut Bordet, BE
• Elia Biganzoli – Univeristy of Milan, IT
• Patrick Derksen – UMC Utrecht, NL
• Rita Mukthar – University of California San Francisco, USA
• Lori Pettiti – Independent ILC advocate, USA
• François Richard – KU Leuven, BE
• Claire Turner – Lobular Breast Cancer UK, EBLCAdvocates

Metastatic ILC

• Christine Desmedt – KU Leuven, BE
• Amanda Fitzpatrick – King’s College London, UK
• Rachel Jankowitz – University of Pennsylvania, USA
• Adrian Lee – UPMC, USA
• Julia K. Levine – Lobular Breast Cancer Alliance, USA
• Christine McKay – Independant Patient Advocate
• Jose Sandoval – Institut Curie, FR

Tumor microenvironment

• Val Brunton – University of Edinburgh, UK
• Tracy Cushing – Front Range ILC
• Thys Koorman – UMC Utrecht, NL
• Fatima Mechta-Grigoriou – Institut Curie, FR
• Steffi Oesterreich – UPMC, USA
• Pamela Robinson Kinnon – Lobular Breast Cancer Australia
• George Sflomos – EPFL, CH

Hormonal and genetic risk factors

• Esther Geven – EBLCAdvocates
• Fabienne Lesueur – Institut Curie, FR
• Elinor Sawyer – King’s College London, UK
• Rian Terveer – EBLCAdvocates

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You can find the Program Book Here.

Please find below the list of selected abstract for the ILC Symposium 2024.

Abstract ID	First name	Last Name	Institute or Affiliation:	Abstract Title:
ORAL	William	Yang	Institute of Cancer Research	E-cadherin/Aurora-A kinase inhibitor synthetic lethality highlights novel therapeutic vulnerabilities for targeting metastatic lobular breast cancer.
ORAL	Eduardo	Pena	King’s College London	Insights into the Transcriptomic and Immune Heterogeneity of Pleomorphic Invasive Lobular Breast Cancer
ORAL	Gitte	Zels	KU Leuven	Clinical and histopathological characterisation of metastatic invasive lobular breast cancer: lessons learned from post-mortem tissue donation programs
ORAL	Sana	Shabbir	University of Edinburgh	Role of Interleukin-6 in regulating estrogen signaling and endocrine therapy resistance in Invasive Lobular Carcinoma
ORAL	Insa	Thale	University of Pittsburgh	Characterization of a Syngeneic ER+ Mouse Model Representing Invasive Lobular Breast Carcinoma
ORAL	Abdalla	Wedn	Women’s Cancer Research Center, Magee Women’s Research Institute, UPMC Hillman Cancer Center, Pittsburgh, PA, USA	Hypomethylation and over-expression of AP2b in ILC causes increased growth due to effects on cell cycle
POSTER-01	Guilherme	Nader Marta	Dana-Farber Cancer Institute	Subtype-specific prognostic value of lobular histology in patients with early-stage breast cancer: a nationwide population-based study
POSTER-02	Lounes	Djerroudi	Institut Curie	Clinico-pathological Characteristics of Breast Invasive Lobular Carcinoma in non-CDH1 genetic predisposition. Experience from the Institut Curie.
POSTER-03	Matteo	Serra	Institut Jules Bordet	Spatial Transcriptomics-Derived Classification of Invasive Lobular Carcinoma: Associations with Clinical, Genomic Characteristics, and Prognosis
POSTER-04	Azime	AKÇAÖZ-ALASAR	Izmir Institute of Technology	ANALYSIS OF m6A RNA MODIFICATION PATTERNS IN INVASIVE LOBULAR BREAST CANCER
POSTER-05	Aeree	Kim	Korea University Guro Hospital	Comprehensive characterization of invasive mammary carcinoma with lobular features: Integrating morphology and E-cadherin immunochemistry pattern
POSTER-06	Karen	Van Baelen	KU Leuven	Clinical challenges and proposed solutions for invasive lobular breast cancer
POSTER-07	Azadeh	Nasrazadani	MD Anderson Cancer Center	Invasive lobular carcinoma is rarely seen in inflammatory breast cancer and confers an inferior prognosis.
POSTER-08	Esme	Bullock	University of Edinburgh	Cancer-associated fibroblast driven paracrine IL-6/STAT3 signalling promotes migration and dissemination of Invasive Lobular Carcinoma cells.
POSTER-09	Naomi	Eastwood	University of Manchester	Deciphering the Transcription Factor Network and Enhancer Activity Controlled by ARID1A in Lobular Cancers
POSTER-10	Jagmohan	Hooda	University of Pittsburgh	Establishing a Comprehensive Living Biobank of ILC Patient-Derived Organoids to Advance Breast Cancer Research
POSTER-11	Morgan	Cody	University of Pittsburgh School of Medicine	Is there mis and/or late diagnosis of metastatic ILC? A quantitative and qualitative analysis
POSTER-12	Sumayya	Abdul Qadir	University of Toronto	Developing and Characterizing Models for Recurrent Invasive Lobular Breast Carcinoma with Nf1 and HER2/Neu Mutations
POSTER-13	Laura	Kennedy	Vanderbilt University Medical Center	Targeted Neoadjuvant Treatment Trial for HER2-mutated Lobular Breast Cancer (Trial in Progress)
POSTER-14	Chinasa A	Ufondu	Department of Pharmacology, Molecular Pharmacology and Therapeutics (MPaT), University of Minnesota, Twin Cities.	Unique interactions between E-cadherin loss and Estrogen receptor drive tumorigenesis in Invasive Lobular Cancer.
POSTER-15	Jie Bin	Liu	University of Pittsburgh	Destabilizing HER2 with Neratinib or Ganetespib Enhances Preclinical Efficacy of Trastuzumab Deruxtecan in HER2-mutant Invasive Lobular Breast Cancer
POSTER-16	Anne	Vincent-Salomon	Institut Curie	Breast cancer subtypes: a patient’s survey with a special focus on lobular breast cancer
POSTER-17	Laurie	Hutcheson	Lobular Breast Cancer Alliance Inc.	Worldwide Collaboration Among Invasive Lobular Carcinoma Researchers and Patient Advocates Produces October 15th Global Lobular Breast Cancer Awareness Day
POSTER-18	Claire	Turner	Lobular Breast Cancer UK	Changing UK Breast Cancer Treatment Guidelines Authors: Helen Coulthard1, Sara MacLennan2, Claire Turner3, 1. De Montfort University & Lobular Breast
POSTER-19	Helen	Coulthard	De Montfort University	The co-creation of digital postcards to support those with an Invasive Lobular Carcinoma diagnosis

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Social Activities

Book the activities of your choice via the registration form (link on top). They are all free except the dinner at Troubadour on the 24^th for which a participation fee is requested. Of note, registration is not required for the lab tour.

23^rd of September 

Lab tour – morning (10am-12am) 

A quick tour of the laboratory for translational breast cancer research (LTBCR, headed by Prof. Desmedt) will be organized for the patient advocates. In addition, main core facilities of the UZ/KU Leuven Campus will be presented. 

Walking tours – evening (6:30pm-8pm) 

As part of our conference experience, we’re excited to offer all participants a complimentary walking tour of this charming Belgian city. Immerse yourself in the rich history, stunning architecture, and vibrant culture of Leuven while getting to know your fellow attendees in a relaxed and active setting. You can choose between two options:   

• 3km Walking Tour: Explore the highlights of Leuven in a leisurely 1.5-hour stroll. 
• 5km Walking Tour (including Heverlee): Extend your adventure to include Heverlee and Arenberg.  

Please note that dinner afterwards is not included. However, Leuven offers an array of delightful restaurants and cafes where you can continue your adventure and socialize with newfound friends from the tour. 

24^th of September 

Group picture –  (11:00m) 

To get a nice memory, we plan to get a group picture at the Irish College. Depending of our famous Belgian weather, the picture could be taken from inside our outside.

Dinner at Troubadour –  evening (7:30pm) 

 

Tiensestraat 32, 3000 Leuven. 

We will close the first day of our symposium by a warm gathering at the Troubadour restaurant (https://www.troubadour.be/) located in the historical centre of Leuven. 

25^th of September 

Early run – morning (7am) 

In order to start the last day of the symposium fully energized, we propose having a short morning run starting from the Irish College Leuven. Another way of discovering Leuven. 

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GRASP Poster Meetup

GRASP (Guiding Researchers and Advocates to Scientific Partnerships) is a patient-led organization that connects and empowers patients, clinicians, and researchers to exchange ideas and learn from each other. The in-person Poster Meetup will take place during the poster session and will bring scientists and patient advocates together for small group discussions about posters being presented at medical and scientific conferences.

The GRASP philosophy is that all participants have unique experiences and can add to the discussion. Unlike traditional presentations, GRASP adopts a conversational approach whereby patient advocates are encouraged to share their personal experiences, whether as cancer survivors or caregivers, shedding light on the profound impact of cancer on their lives.

GRASP seeks to create a bi-directional interactive learning environment whereby:

1. Scientists can engage directly with the people they dedicate their lives to helping, bringing a sense of urgency and purpose to their work;
2. Researchers can fine tune their communication skills by discussing their work with a nonscientific audience who is invested and eager to learn;
3. Patient advocates can understand scientific processes in a robust and meaningful manner, giving them hope for longer and better lives that only research can provide.

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For Breast Cancer Advocates

The meeting will be open for community members, and we will make an effort to distribute information on ILC in lay language. A representative patient advocate group is working on an agenda focused on patients, their families and advocates. We will post updates here.

Selected scientific sessions (based on speakers’ consent) will be recorded and posted on the ILC symposium website after the end of the Symposium (similar to what was done for prior ILC Symposia). It will be available for free, and no registration is required to watch the recorded sessions.

Digital Toolkit for Advocates

We are delighted to present the “Digital Toolkit for Advocates” designed exclusively for patient advocates attending the ILC Symposium 2024. This comprehensive toolkit is aimed at enhancing your symposium experience by providing valuable resources and empowering you in your advocacy journey.

Inside the toolkit, you’ll find a treasure trove of resources, including:

📽️ Video Recordings: Access video recordings of past symposium sessions to catch up on valuable insights shared by renowned experts in the field.

🎧 Instructive Recordings: Dive deeper into instructive sessions that offer valuable tips and advice on patient advocacy, communication, and empowerment.

🔗 Links to Advocacy Resources: Discover a curated collection of links to advocacy resources, including Facebook groups and other online platforms where you can connect with like-minded advocates.

💡 Useful Resources: Find a compilation of valuable resources, documents, and informative materials that can aid you in your advocacy efforts.

This Digital Toolkit is your companion throughout the symposium and beyond, offering a wealth of knowledge and support to enhance your advocacy journey. We hope these resources empower you to make a positive impact in the field of invasive lobular breast cancer research.

Click here to access the Digital Toolkit for Advocates

Content from the ILC Symposium 2023

CLICK HERE for the ILC Workshop Agenda 2023

Session 1 Slides (2023)

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Sponsors

Platinum Level

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Gold Level

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Silver Level

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Scientific Organizing Committee

Local Organizing Committee

GlobMob (Patient Advocate) Organizing Committee

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The Irish College Leuven

🌟 Welcome to Leuven: Where History and Charm Await! 🌟 

Explore the heart of Belgium in Leuven, where medieval architecture, vibrant culture, and academic prestige converge. Wander cobblestone streets past ancient buildings and discover treasures like the UNESCO-listed St. Peter’s Church and the renowned University Library. The conference will be held in the captivating Irish College Center, a historic institution dating back to the 17th century. 

_{Photo credits: Peter Mooney}

Janseniusstraat 1
Leuven, 3000 Belgium

Find out how to come here !

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